' 
SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.2
USERS' SCORE
Good
Based on 1 Review
8
Supplement Facts
Serving Size: 2 Tablets
Amount Per Serving
%DV
Calcium (elemental) (from 2,775 mg complex of Calcium Carbonate, Calcium Citrate, Calcium Ascorbate)
1 g (1,000 mg)
77%
Magnesium (elemental) (from 928 mg complex of Magnesium Oxide, Magnesium Citrate, Magnesium Ascorbate)
500 mg
119%
Top Medical Research Studies
8
Magnesium nanoparticles inhibit cancer growth
Magnesium whitlockite nanoparticles: Hydrothermal synthesis, anti-inflammatory and anti-cancer potential.
Direct relevance to breast cancer
We investigated the effects of magnesium whitlockite nanoparticles, or WH NPs, and their potential role in combating breast cancer. By synthesizing these nanoparticles and exploring their various properties, we aimed to understand how they could influence inflammation and cancer cell growth.
Our detailed analyses revealed that WH NPs are derived from brushite with magnesium ions introduced during a hydrothermal process. In the context of breast cancer, we observed that these nanoparticles exhibited notable anti-cancer activity by effectively inhibiting the proliferation of MDA-MB-231 breast cancer cells.
Additionally, WH NPs demonstrated anti-inflammatory effects, significantly lowering the production of important markers associated with inflammation. This dual action of reducing inflammation and targeting cancerous cells suggests a promising avenue for innovative treatments in the fight against breast cancer.
Our detailed analyses revealed that WH NPs are derived from brushite with magnesium ions introduced during a hydrothermal process. In the context of breast cancer, we observed that these nanoparticles exhibited notable anti-cancer activity by effectively inhibiting the proliferation of MDA-MB-231 breast cancer cells.
Additionally, WH NPs demonstrated anti-inflammatory effects, significantly lowering the production of important markers associated with inflammation. This dual action of reducing inflammation and targeting cancerous cells suggests a promising avenue for innovative treatments in the fight against breast cancer.
Read More
8
MeJa stimulates magnesium-induced apoptosis
Methyl Jasmonate-induced Increase in Intracellular Magnesium Promotes Apoptosis in Breast Cancer Cells.
Direct link to magnesium in cancer
We explored the effects of methyl jasmonate (MeJa), a plant hormone, on breast cancer cells, specifically looking at how it influences intracellular magnesium levels and cell death. Our study used the MCF-7 breast cancer cell line to analyze these interactions.
In our approach, we assessed cell viability through an MTT assay and measured magnesium concentrations using advanced spectrophotometry. We also looked at how MeJa affects ATP levels, reactive oxygen species (ROS), and the MAPK signaling pathway, which are all crucial in understanding cancer cell behavior.
We found that increased magnesium levels led to reduced expression of TRPM7, a magnesium transporter, which directly correlated with higher ROS production and signs of stress in the cell. As a result, we observed that these changes contributed to increased apoptosis, or programmed cell death, in the breast cancer cells.
Ultimately, our findings suggest that manipulating magnesium levels might provide a novel pathway through which MeJa promotes cell death in breast cancer, offering insight into potential treatment strategies.
In our approach, we assessed cell viability through an MTT assay and measured magnesium concentrations using advanced spectrophotometry. We also looked at how MeJa affects ATP levels, reactive oxygen species (ROS), and the MAPK signaling pathway, which are all crucial in understanding cancer cell behavior.
We found that increased magnesium levels led to reduced expression of TRPM7, a magnesium transporter, which directly correlated with higher ROS production and signs of stress in the cell. As a result, we observed that these changes contributed to increased apoptosis, or programmed cell death, in the breast cancer cells.
Ultimately, our findings suggest that manipulating magnesium levels might provide a novel pathway through which MeJa promotes cell death in breast cancer, offering insight into potential treatment strategies.
Read More
8
Magnesium's role in breast cancer
Evaluation of biogenically synthesized MgO NPs anticancer activity against breast cancer cells.
High relevance to study topic
We observed the potential of magnesium oxide nanoparticles (MgO NPs) in fighting breast cancer, particularly against the MDA-MB-231 cell line. Through a variety of biological tests—like measuring how these nanoparticles affect cell survival, induce cell death, and cause oxidative stress—we aimed to determine their effectiveness as a treatment option.
Our findings showed that MgO NPs significantly increased cytotoxic effects, leading to cell death. Not only did we see a rise in reactive oxygen species (ROS) production, but we also noted improved cell adhesion and decreased cellular migration, suggesting that these nanoparticles might hinder cancer progression in a measurable way.
While these results are promising, we recognize that further studies, including research on animal models or human trials, are necessary. Validating these findings in more complex systems will be crucial for confirming MgO NPs as a viable cancer treatment.
Our findings showed that MgO NPs significantly increased cytotoxic effects, leading to cell death. Not only did we see a rise in reactive oxygen species (ROS) production, but we also noted improved cell adhesion and decreased cellular migration, suggesting that these nanoparticles might hinder cancer progression in a measurable way.
While these results are promising, we recognize that further studies, including research on animal models or human trials, are necessary. Validating these findings in more complex systems will be crucial for confirming MgO NPs as a viable cancer treatment.
Read More
Most Useful Reviews
3.5
Not effective for everyone
After a month of use, my mother experienced painful breasts, so she discontinued this supplement and everything returned to normal.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.2
- All Researches
9
Calcium's role in breast cancer treatment
Dual-Gating Strategy: Ultrasound Activation of TRPV2 Channels and Borate-Glass-Induced Calcium Overload for Tumor Suppression.
Calcium effects combined with treatments
We delved into the potential of calcium in breast cancer treatment using a dual-gating strategy that employs borate glass (BG) and ultrasound (US). Our approach specifically targets the transient receptor potential vanilloid 2 (TRPV2) channels, which are often overexpressed in breast cancer cells.
After local application of BG to the tumor, we saw that US effectively activated these TRPV2 channels. This activation led to an overload of calcium within the cancer cells, ultimately triggering mitochondrial autophagy and apoptosis, or cell death. This mechanism allowed us to inhibit tumor growth with remarkable precision.
Through testing in various mouse models, including subcutaneous and orthotopic models, as well as those with TRPV2 overexpression, we validated our results. In cases involving bone metastasis, the combined treatment of BG and US not only hindered tumor growth but also encouraged bone regeneration.
Overall, our findings illuminate a promising avenue for precise cancer therapies that hinge on calcium overload, particularly for tumors exhibiting high levels of TRPV2 expression. While we explored the synergy of calcium with other treatments, it’s worth noting that assessing the isolated impact of calcium was challenging.
After local application of BG to the tumor, we saw that US effectively activated these TRPV2 channels. This activation led to an overload of calcium within the cancer cells, ultimately triggering mitochondrial autophagy and apoptosis, or cell death. This mechanism allowed us to inhibit tumor growth with remarkable precision.
Through testing in various mouse models, including subcutaneous and orthotopic models, as well as those with TRPV2 overexpression, we validated our results. In cases involving bone metastasis, the combined treatment of BG and US not only hindered tumor growth but also encouraged bone regeneration.
Overall, our findings illuminate a promising avenue for precise cancer therapies that hinge on calcium overload, particularly for tumors exhibiting high levels of TRPV2 expression. While we explored the synergy of calcium with other treatments, it’s worth noting that assessing the isolated impact of calcium was challenging.
Read More
8
Magnesium nanoparticles inhibit cancer growth
Magnesium whitlockite nanoparticles: Hydrothermal synthesis, anti-inflammatory and anti-cancer potential.
Direct relevance to breast cancer
We investigated the effects of magnesium whitlockite nanoparticles, or WH NPs, and their potential role in combating breast cancer. By synthesizing these nanoparticles and exploring their various properties, we aimed to understand how they could influence inflammation and cancer cell growth.
Our detailed analyses revealed that WH NPs are derived from brushite with magnesium ions introduced during a hydrothermal process. In the context of breast cancer, we observed that these nanoparticles exhibited notable anti-cancer activity by effectively inhibiting the proliferation of MDA-MB-231 breast cancer cells.
Additionally, WH NPs demonstrated anti-inflammatory effects, significantly lowering the production of important markers associated with inflammation. This dual action of reducing inflammation and targeting cancerous cells suggests a promising avenue for innovative treatments in the fight against breast cancer.
Our detailed analyses revealed that WH NPs are derived from brushite with magnesium ions introduced during a hydrothermal process. In the context of breast cancer, we observed that these nanoparticles exhibited notable anti-cancer activity by effectively inhibiting the proliferation of MDA-MB-231 breast cancer cells.
Additionally, WH NPs demonstrated anti-inflammatory effects, significantly lowering the production of important markers associated with inflammation. This dual action of reducing inflammation and targeting cancerous cells suggests a promising avenue for innovative treatments in the fight against breast cancer.
Read More
8
Magnesium-curcumin complex shows promise
The Antitumoral Effect In Ovo of a New Inclusion Complex from Dimethoxycurcumin with Magnesium and Beta-Cyclodextrin.
Focus on magnesium-curcumin complex
We explored how a new inclusion complex made from dimethoxycurcumin and magnesium influences breast cancer cell behavior, particularly in the context of MDA-MB-231 cells, a line known for its aggressiveness. The study demonstrated that this new compound, which was combined with beta-cyclodextrin to enhance solubility, significantly altered cell metabolism and morphology, slowed cell migration, and induced apoptosis in cancer cells.
Importantly, the complex also reduced levels of specific inflammatory markers and transcription factors linked to cancer aggression. When tested in an in ovo model, we observed that this magnesium-curcumin complex could inhibit tumor growth by up to 30%. In contrast, the free magnesium complex demonstrated a lesser inhibition of 17.29%, showcasing the enhanced efficacy of the inclusion complex form.
Overall, while magnesium in isolation wasn't the focus, our findings suggest that the magnesium-curcumin inclusion complex offers promising therapeutic potential against breast cancer, particularly due to its improved solubility and effectiveness.
Importantly, the complex also reduced levels of specific inflammatory markers and transcription factors linked to cancer aggression. When tested in an in ovo model, we observed that this magnesium-curcumin complex could inhibit tumor growth by up to 30%. In contrast, the free magnesium complex demonstrated a lesser inhibition of 17.29%, showcasing the enhanced efficacy of the inclusion complex form.
Overall, while magnesium in isolation wasn't the focus, our findings suggest that the magnesium-curcumin inclusion complex offers promising therapeutic potential against breast cancer, particularly due to its improved solubility and effectiveness.
Read More
8
MeJa stimulates magnesium-induced apoptosis
Methyl Jasmonate-induced Increase in Intracellular Magnesium Promotes Apoptosis in Breast Cancer Cells.
Direct link to magnesium in cancer
We explored the effects of methyl jasmonate (MeJa), a plant hormone, on breast cancer cells, specifically looking at how it influences intracellular magnesium levels and cell death. Our study used the MCF-7 breast cancer cell line to analyze these interactions.
In our approach, we assessed cell viability through an MTT assay and measured magnesium concentrations using advanced spectrophotometry. We also looked at how MeJa affects ATP levels, reactive oxygen species (ROS), and the MAPK signaling pathway, which are all crucial in understanding cancer cell behavior.
We found that increased magnesium levels led to reduced expression of TRPM7, a magnesium transporter, which directly correlated with higher ROS production and signs of stress in the cell. As a result, we observed that these changes contributed to increased apoptosis, or programmed cell death, in the breast cancer cells.
Ultimately, our findings suggest that manipulating magnesium levels might provide a novel pathway through which MeJa promotes cell death in breast cancer, offering insight into potential treatment strategies.
In our approach, we assessed cell viability through an MTT assay and measured magnesium concentrations using advanced spectrophotometry. We also looked at how MeJa affects ATP levels, reactive oxygen species (ROS), and the MAPK signaling pathway, which are all crucial in understanding cancer cell behavior.
We found that increased magnesium levels led to reduced expression of TRPM7, a magnesium transporter, which directly correlated with higher ROS production and signs of stress in the cell. As a result, we observed that these changes contributed to increased apoptosis, or programmed cell death, in the breast cancer cells.
Ultimately, our findings suggest that manipulating magnesium levels might provide a novel pathway through which MeJa promotes cell death in breast cancer, offering insight into potential treatment strategies.
Read More
8
Magnesium's role in breast cancer
Evaluation of biogenically synthesized MgO NPs anticancer activity against breast cancer cells.
High relevance to study topic
We observed the potential of magnesium oxide nanoparticles (MgO NPs) in fighting breast cancer, particularly against the MDA-MB-231 cell line. Through a variety of biological tests—like measuring how these nanoparticles affect cell survival, induce cell death, and cause oxidative stress—we aimed to determine their effectiveness as a treatment option.
Our findings showed that MgO NPs significantly increased cytotoxic effects, leading to cell death. Not only did we see a rise in reactive oxygen species (ROS) production, but we also noted improved cell adhesion and decreased cellular migration, suggesting that these nanoparticles might hinder cancer progression in a measurable way.
While these results are promising, we recognize that further studies, including research on animal models or human trials, are necessary. Validating these findings in more complex systems will be crucial for confirming MgO NPs as a viable cancer treatment.
Our findings showed that MgO NPs significantly increased cytotoxic effects, leading to cell death. Not only did we see a rise in reactive oxygen species (ROS) production, but we also noted improved cell adhesion and decreased cellular migration, suggesting that these nanoparticles might hinder cancer progression in a measurable way.
While these results are promising, we recognize that further studies, including research on animal models or human trials, are necessary. Validating these findings in more complex systems will be crucial for confirming MgO NPs as a viable cancer treatment.
Read More
User Reviews
USERS' SCORE
Good
Based on 1 Review
8
- All Reviews
- Positive Reviews
- Negative Reviews
3.5
Not effective for everyone
After a month of use, my mother experienced painful breasts, so she discontinued this supplement and everything returned to normal.
